131. O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 2009 Nov;10(5):430-5. (Pubmed)

130. Curran, S. P. X. Wu, C. Riedel, and G. Ruvkun. 2009. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature Jun 25;459(7250):1079-84. Epub 2009 Jun 7. (Pubmed)

129.  Ruvkun, G. 2009.  Signaling pathways that regulate C. elegans lifespan, Ipsen Fondation Series. Paris.

128.  Butcher, R.A., J. R. Ragains, G. Ruvkun, J. Clardy, H. Y. Mak.  2009. Biosynthesis of the Caenorhabditis elegans dauer pheromone.  Proceedings of the National Academy of Sciences 106(6):1875-9. (Pubmed, Journal)

127. Soukas, A. A., E. A. Kane, C. E. Carr, J. A. Melo, and G. Ruvkun.  2009.  Rictor/TORC2 regulates fat metabolism, feeding, growth, and lifespan in Caenorhabditis elegans. Genes and Development 23: 496-511. (Pubmed, Journal)

126. Isenbarger, T.A, C. E. Carr, S. S. Johnson, M. Finney, G. M. Church, W. Gilbert, M. T. Zuber, and G. Ruvkun. 2008. The most conserved genome segments for life detection on Earth and other planets, Origin of Life and Evolution of Biospheres, 38(6):517-33. Oct 14. (Pubmed)

125. Wang, M. C., E. O’Rourke and G. Ruvkun. 2008. Fat metabolism links germline stem cells and longevity in C. elegans. Science 322: 957-60. (Pubmed)

124. Ruvkun G. 2008. The perfect storm of tiny RNAs. Nat Med. 14:1041-5. (Pubmed)

123. Fischer, S.E.J., M. D. Butler, Q. Pan and G. Ruvkun. 2008. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature 455: 491-6. (Pubmed)

122. Ruvkun, G. 2008. Tiny RNA: Where do we come from? What are we? Where are we going? Trends Plant Sci. 13 :313-6. (Pubmed)

121. Simon D.J., Madison J.M., Conery A.L., Thompson-Peer K.L., Soskis M., Ruvkun G., Kaplan J.M., Kim J.K. 2008. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell 133: 903-15. (Pubmed)

120. Patel D.S., Fang L.L., Svy D.K., Ruvkun G., Li W. 2008. Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development. 135: 2239-49. (Pubmed)

119. Gabel, H. W. and G. Ruvkun. 2008. The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.  Nat Struct Mol Biol. 15: 531-3. (Pubmed)

118. Samuelson, A.V., R. R. Klimczak, D. Thompson, C. E. Carr, and G. Ruvkun. 2008.  Identification of C. elegans genes regulating longevity using enhanced RNAi-sensitive strains.  Cold Spring Harb Symp Quant Biol. 2007;72:489-97. (Pubmed)

117. Pierce M.L., Weston M.D., Fritzsch B., Gabel H.W., Ruvkun G., Soukup G.A. 2008. MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev. 10(1):106-13. (Pubmed)

116. Isenbarger, T. A. , M. Finney, C. Ríos-Velázquez, J. Handelsman, and G. Ruvkun. 2007. Miniprimer PCR, a new lens for viewing the microbial world.  Appl Environ Microbiol. 2008 Feb;74(3):840-9. (Pubmed)

115. Parry, D.H., Xu, J. and G. Ruvkun. 2007. A whole-genome RNAi screen for C. elegans miRNA pathway genes.  Current Biology 17: 2013-22. (Pubmed)

114. Samuelson, A. V. , Carr, C. E., and G. Ruvkun. 2007. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.  Genes and Development 21:2976-94. (Pubmed)

113. Kim N, Dempsey C, Kuan CJ, Zoval J, O'Rourke E, Ruvkun G, Madou M, Sze J. 2007. Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in C. elegans. Genetics. 177:835-45.

112. Curran, S. P. and G. Ruvkun. Lifespan regulation by evolutionarily conserved genes essential for viability.  2007.  PloS Genetics 3(4):e56.

111. Hayes, GD and G. Ruvkun. 2006. Misexpression of the C. elegans miRNA let‑7 is sufficient to drive developmental programs. Cold Spring Harbor Symp Quant Biol. 71: 21-7. Regulatory RNAs.

110.  Ruvinsky, I., U. Ohler, C. B. Burge, and G. Ruvkun. 2006. Detection of broadly expressed neuronal genes in C. elegans. Dev Biol. 302: 617-26.

109.  Hayes, G. D. A. R. Frand, and G. Ruvkun. 2006. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development 133: 4631-4641.

108. Hu, P.J., J. Xu, and G. Ruvkun. 2006. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006 Jul;2(7):e99.

107. Sandoval, G.M., J. S. Duerr, J. Hodgkin, J. B. Rand & G. Ruvkun. 2006.  A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans.  Nature Neuroscience, 9:599-601.

106. Mak, H.Y., L.S. Nelson, M. Basson, C. D. Johnson and G. Ruvkun. 2006. Polygenic control of C. elegans fat storage.  Nature Genetics 38:363-8.

105. Duchaine, T.F, J. A. Wohlschlegel, S. Kennedy, Y. Bei, D. Conte, K. Pang, D.R. Brownell, S. Harding, S. Mitani, G. Ruvkun, J. R. Yates, and C. C. Mello.  2006.  Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.  Cell 124:343-54.

104. Frand, A.R., S. Russel, G. Ruvkun  2005. Genes essential for C. elegans molting revealed through a genome-wide RNA-interference screen. PLoS, 3:e312 [Epub ahead of print].

103. Wang, D. S. Kennedy, D. Conte, J. Kim, H. Gabel, R. Kamath, C. Mello, and G. Ruvkun.  2005. Somatic misexpression of germline P granules and enhanced RNA interference in C.elegans Retinoblastoma pathway mutants. Nature 436: 593-597.

102. Sieburth, D, Q. Ch ng, M. Dybbs, M. Tavazoie, S. Kennedy, D. Wang, D. Dupuy, J. Rual, D. Hill, M. Vidal, G. Ruvkun, and J. Kaplan.  2005.  Systematic analysis of genes required for synapse structure and function. Nature 436: 510-517.

101. Hamilton, B. , Y. Dong, M. Shindo, W. Liu, G. Ruvkun, and S. S. Lee. 2005. A systematic RNAi screen for longevity genes in C. elegans. Genes and Development 19:1544-55.

100. Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P.  2005. Analysis of xbx genes in C. elegans. Development. 132:1923-34.

99. Kim, J.K, , H. W. Gabel, R. S. Kamath, M. Tewari, A. Pasquinelli, S. Kennedy, M. Dybbs, N. Bertin, M. Vidal, J. M. Kaplan, and G. Ruvkun  2005. Functional genomic analysis of RNA interference in C. elegans. Science 308: 1164-7.

98. Wang, D. and G. Ruvkun. 2004. The insulin pathway regulates RNAi in C. elegans.  Cold Spring Harbor Symposium on Quantitative Biology, 69th edition, 69: 429-433.

97. Ruvkun, G., J. Kim, G. Hayes, S. Kennedy, D. Wang, K. Ashrafi. 2004.  The Tiny RNA World.  Harvey Lecture 99: 1-21.

96. Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT. 2004. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 36:1079-83

95. Mak, H. Y. and G. Ruvkun. 2004. Cell nonautonomous role of DAF-9 cytochrome P450 in C. elegans larval development and gonadal migration. Development, 131:1777-86.

94. Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M. 2004.  Systematic genetic perturbation analysis of a Caenorhabditis elegans TGF-ß protein interaction network.  Molecular Cell 13:469-82.

93. Kennedy, S.K., D. Wang, and G. Ruvkun.  2004. A conserved siRNA degrading RNase negatively regulates RNA interference in C. elegans Nature 427: 645-9.

92. Ruvkun, G., B. Wightman, and I. Ha. 2004. The 20 years it took to recognize the importance of tiny RNAs. Cell S116: S93–S96,

91. Kim, J , Krichevsky, A., Grad, Y., Hayes, G.D., Kosik, K.S. , Church, G. M. , and G. Ruvkun. 2004.  Identification of many mammalian neuron-expressed microRNAs that co-purify with polysomes, Proc. Natl. Acad. Sci.101: 360-5.

90. Komaroff AL, Ruvkun G.

89. Sze, J.Y. and G. Ruvkun. 2003. Olfactory hypersensitivity and hyperadaptation in C. elegans caused by activation of the UNC-86 POU transcription factor, Proc. Natl. Acad. Sci., 100:9560-5.

88. Ruvinsky, I. and G. Ruvkun  2003. Functional tests of enhancer conservation between distantly related species, Development, 130:5133-42.

87. Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T. 2003. A uniform system for microRNA annotation. RNA. 9: 277-279.

86. Garsin, D.A. J. M. Villanueva, J. Begun, D. H. Kim, C. D. Sifri, S. B. Calderwood, G. Ruvkun, and F. M. Ausubel. 2003. Long-Lived Caenorhabditis elegans daf-2 Mutants are Resistant to Bacterial Pathogens, Science, 300:1921.

85. Grad, Y., Aach, J., Hayes, G.D., Reinhart, B. , Church, G. M. , Ruvkun, G., and J. Kim. 2003. Computational and experimental identification of C. elegans microRNAs. Molecular Cell, 11:1253-63.

84. Lee, S.S., Kennedy,S., Tolonen,A.C. and G. Ruvkun. 2003. DAF-16 target genes that control C. elegans life-span and metabolism. Science. 300:644-7

83. Aspöck, G, Ruvkun, G., and T. R. Bürglin. 2003. The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development, 130:3369-3378.

82 Pasquinelli, A.E., McCoy, A. Jimenez, E. , Salo, E., , Ruvkun, G. , Martindale, M. Q. and J. Baguñà 2003. Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: A role in life history evolution?  Evolution and Development, 5:372-378.

81. Bashirullah, A., Pasquinelli, A.E. Kiger, A., Perrimon, N, Ruvkun, G., and C. S. Thummel 2003. Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis.  Developmental Biology, 259:1-8.

80. Li, W. and G. Ruvkun 2003. daf-28 encodes a C. elegans insulin like ligand that acts in the DAF-2 insulin like signaling pathway and is regulated by environmental cues. Genes and Development, 17: 844-58.

79. Ashrafi, K., Chang, FY,.Watts, JL, Fraser, AG, Kamath, RS, Ahringer, J. and G. Ruvkun 2003. Genome-wide RNAi analysis of C. elegans fat regulatory genes. Nature, 421:268-72.

78. Lee, S.S., Lee, R.Y., Fraser, AG, Kamath, RS, Ahringer, J. and G Ruvkun 2002. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nature Genetics, 33:40-8.

77. Wolkow CA, Munoz MJ, Riddle DL, G. Ruvkun. 2002. Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem. 277:49591-7.

76. Lee S.S, and Ruvkun G. 2002. Longevity: don't hold your breath. Nature. 418:287-8.

75. Ruvkun, G., M. Finney, G. Church, M. Zuber, W. Gilbert 2002. A Robotic-PCR Detector for DNA-based Life on Other Planets, in Signs of Life: A Report based on the April 2000 Workshop on Life Detection Techniques. Space Sciences Board, NASA.

74. Pasquinelli, A.E. and G. Ruvkun 2002. Control of developmental timing by microRNAs and their targets. Ann. Rev. Cell Biology., 18:495-513.

73. Sze, J.Y., Zhang, S., Li, J., and G. Ruvkun 2002 The C elegans POU-domain transcription factor UNC-86 regulates the tph-1 hydroxylase gene and neurite outgrowth in particular serotonergic neurons. Development, 129:3901-11

72. Lee, R.Y.N., Hench, J., and G. Ruvkun 2001. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol. 11: 1950-1957.

71. Ruvkun, G. 2001. Glimpses of the tiny RNA world. Science 294:797-9.

70. Finch, C.E. and G. Ruvkun 2001. The Genetics of Aging. Ann. Rev. Genomics and Human Genetics 2: 435-462

69. Grishok, A., Pasquinelli, A.E., Conte, D., Li, N., Parrish, S., Ha, I., Baillie, D.L., Fire, A., Ruvkun, G., and Mello, C.C. 2001. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control Caenorhabditis elegans developmental timing. Cell 106: 23-34.

68. Pierce, S.B., Costa, M., Wisotzkey, R. , Devadhar, S., Homburger, S.A., Buchman, A.R., Ferguson, K.C., Heller, J., Platt, D.M. , Liu, L.X. , Pasquinelli, A.E., Doberstein, S.K. , G. Ruvkun. 2001. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes and Development 15: 672-686.

67. Bürglin, T.R. and G. Ruvkun 2001. Regulation of ectodermal and excretory cell function by the C. elegans POU homeobox gene ceh-6 Development 128: 779-790.

66. Reinhart, B.J. and G. Ruvkun. 2001. Isoform-specific mutations in the Caenorhabitis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics 157: 199-209.

65. Cahill, C.M., Tzivion, G., Nasrin, N., Ogg, S., Dore, J., Ruvkun, G., and M. Alexander-Bridges. 2001. PI-3 kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3 dependent and independent pathways. J. Biol. Chem. 276: 13402-10.

64. Wolkow, C.A., Kimura, K.D., Lee, M. and G. Ruvkun. 2000. C. elegans lifespan is regulated by insulin-like signaling in the nervous system. Science 290:147-50.

63. Pasquinelli, A., Reinhart, B., Slack F. , Maller, B., Kuroda, M., Martindale, M., Srinivasan, A., Fishman, M., Hayward. D., Ball. E., Degnan, B., Müller, P. , Spring, J., Finnerty, J., Corbo, J., Levine, M., Leahy, P. , Davidson, E., and G. Ruvkun. 2000. Conservation across animal phylogeny of the sequence and temporal expression of the 21 nucleotide let-7 heterochronic regulatory RNA. Nature 408: 86-89.

62. Nasrin, N., Ogg, S., Cahill, C., Biggs, W., Nui, S., Dore, J., Calvo, D., Shi, Y., Ruvkun, G., and M. Alexander-Bridges. 2000. DAF-16 recruits the CBP co activator to the IGFBP-1 promoter in HepG2 cells. Proc. Natl. Acad. Sci., 97: 10412-7.

61. Kagoshima, H, Sommer, R., Reinhart, B. , Ruvkun, G., Cassata, G., and T. R. Bürglin. 2000. A graded hypodermal expression of ceh-14 induced by a gonadal signal. Development Genes and Evolution 210:564-569.

60. Slack, FJ, Basson, M., Liu, Z., Ambros, V., Horvitz, H.R., and G. Ruvkun. 2000. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the lin-29 transcription factor. Mol. Cell 5: 659-69.

59. Reinhart, B.J., Slack, F.A., Basson, M., Pasquinelli, A.E., Bettinger, J.C., Rougvie, A.C., Horvitz, H.R., and G. Ruvkun. 2000. The 21 nucleotide let-7 RNA regulates C. elegans developmental timing. Nature, 403: 901 - 906.

58. Sze, J.Y., Victor, M., Loer, C., Shi, Y., and G. Ruvkun 2000. Food and metabolic signaling defects in a C. elegans serotonin null mutant, Nature 403: 560-4.

57. Tissenbaum, H.A. Hawdon, J., Perregaux, M. , Hotez, P., Guarente, L., and G. Ruvkun. 2000. A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc. Natl. Acad. Sci. 97: 460-465.

56. Davidson E.H. and G. Ruvkun 1999. Themes from a NASA workshop on gene regulatory processes in development and evolution. J Exp Zool 285: 104-15.

55. Hobert O. and G. Ruvkun 1999. Pax genes in C. elegans : a new twist. Trends Genet 15: 214-216.

54. Sagasti, A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI. 1999. Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes Dev 13: 1794-80.

53. Paradis, S., Ailion, M., Toker A, Thomas, J.H., and G. Ruvkun. 1999. A PDK1 homolog is Necessary and Sufficient to Transduce AGE-1 PI3 Kinase Signals that Regulate Diapause in C. elegans Genes and Development 13: 1438-1452.

52. Hobert O, Tessmar K and G. Ruvkun 1999. The C. elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development 126, 1547-1562

51. Hobert, O., Moerman DG, Clark KA, Beckerle MC, and G. Ruvkun 1999. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol 144: 45-57.

50. Slack F. and G . Ruvkun 1998. A novel repeat domain that is often associated with RING finger and B-box motifs. Trends Biochem Sci 23:474-5.

49. Slack F. and G. Ruvkun 1998 Heterochronic genes in development and evolution. Biol. Bull. 195:375-6.

48. Hobert O. and G. Ruvkun 1998. A common theme for LIM homeobox gene function across phylogeny? Biol. Bull. 195:377-80

47. Guarente L., Ruvkun, G., R. Amasino. 1998. Aging, life span, and senescence. Proc Natl Acad Sci U S A 95:11034-6

46. Slack, F. and G. Ruvkun 1998. Temporal pattern formation by heterochronic genes. Annual Review of Genetics 31: 611-634.

45. Ogg, S. and G. Ruvkun 1998. The C. elegans PTEN homolog daf-18 acts in the insulin receptor-like metabolic signaling pathway. Mol Cell 2: 887-93.

44. Ruvkun, G. and O. Hobert. 1998. The taxonomy of developmental control in Caenorhabditis elegans. Science 282:2033-41.

43. Paradis, S. and G. Ruvkun 1998. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes and Devel. 12:2488-98.

42. Hobert, O., Liu, Y., D’Alberti, T., and G Ruvkun 1998. Control of neural development and function in a thermoregulatory circuit by the LIM homeobox gene lin-11. J. Neuroscience 18: 2084-2096.

41. Tissenbaum, H.A. and G. Ruvkun 1998. An insulin-like signaling pathway affects both longevity and reproduction in C. elegans. Genetics 148: 703-717.

40. Ogg, S., Paradis, S. , Gottlieb, S., Patterson, G.I., Lee, L., Tissenbaum, H.A., and G. Ruvkun 1997. The DAF-16 Fork head-related transcription factor transduces C. elegans insulin-like metabolic and longevity signals. Nature 389: 994-999.

39. Kimura, K.D., Tissenbaum, H.A., Liu, Y. and G. Ruvkun. 1997. daf-2, an insulin receptor-like gene that regulates longevity and diapause in C. elegans. Science 277: 942-946.

38. Patterson, G. I., Koweek, A., Wong, A., Liu, Y., and G. Ruvkun 1997. The DAF-3 Smad protein antagonizes TGF-beta-related receptor signalling in the C. elegans dauer pathway. Genes and Development 11: 2679-2690.

37. Hobert , O., Mori, I., Yamashita, Y., Honda, H., Ohshima, Y., Liu, Y. and G. Ruvkun 1997. Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron 19: 345-357.

36. Sluder, A. E., Lindblom, T. and G. Ruvkun 1997. An early patterning function for the C. elegans nuclear hormone receptor gene nhr-2. Developmental Biology 184: 303-319.

35. Sze, J.Y., Liu, Y. and G. Ruvkun 1997. VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth. Development 124: 1159-1168.

34. Ruvkun, G. 1996. Patterning the C. elegans neuroectoderm. In The Nematode Caenorhabditis elegans, Cold Spring Harbor Press, Cold Spring Harbor, NY, p. 543-581.

33. Ha, I., Wightman, B. and G. Ruvkun 1996. A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes and Development 10: 3041-3050.

32. Barnes, T.M., Jin, Y., Horvitz, H.R., Ruvkun, G., and S. Hekimi 1996. The C. elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and non-specific lipid transfer protein (nsLTP). J. of Neurochemistry 67: 46-57.

31. Morris, J.Z., Tissenbaum, H.A. and G. Ruvkun 1996. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382: 536-538.

30. Baumeister, R., Liu, Y., and G. Ruvkun 1996. Lineage specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Genes and Development 10: 1395-1410.

29. Greenstein, D., Hird, S. Plasterk, R., Andachi, Y., Kohara, Y., Wang, B., Finney, M., and G. Ruvkun 1994. Targeted mutations in the C. elegans POU-homeobox gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation. Genes and Development 8: 1935-1948.

28. Gottlieb, S. and G. Ruvkun 1994. daf-2, daf-16, daf-23: Interacting genes that control dauer formation in C. elegans. Genetics 137: 107-120.

27. Bürglin, T. and G. Ruvkun 1993. The Caenorhabditis elegans homeobox cluster. Current Opinion in Genetics and Development 3: 615-620.

26. Wightman, B., I. Ha, and G. Ruvkun. 1993. Post-transcriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75: 855-862.

25. Ruvkun, G. Generation of temporal and cell lineage asymmetry during C. elegans development. In Molecular Genetics of Development, Springer Verlag, Berlin. 1992.

24. Bürglin, T.R. and G. Ruvkun. 1992. New motif in PBX genes. Nature Genet 1: 319‑320.

23. Ruvkun, G. 1992. A molecular growth industry Nature 360: 711‑712.

22. Xue, D.M., Finney, M., Ruvkun, G. and M. Chalfie. 1992. Regulation of the mec-3 gene by the C. elegans homeoproteins Unc-86 and Mec-3. EMBO J. 11: 4969‑4979.

21. Miller, D., Shen, M., Shamu, C., Bürglin, T., Ruvkun, G., Ghee, M. Dubois, L. Wilson 1992. The C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature 355: 841‑845.

20. Bürglin, T.R., Ruvkun, G., Coulson, A., Hawkins, N., McGhee, J., Schaller, D., Wittmann, C., Müller, F., and Waterston, R. 1991. A nematode homeobox cluster. Nature 351: 703.

19. Ruvkun, G. and M. Finney 1991. Regulation of transcription and cell identity by POU domain proteins. Cell 64: 475‑478.

18. Ruvkun, G., Wightman, B., Bürglin, T.R., and P. Arasu. 1991. Dominant gain of function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern‑formation genes. Development (Supplement): 47‑54.

17. Arasu, P., Wightman, B., G. Ruvkun. 1991. Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28. Genes and Development 5: 1825‑1833.

16. Wightman, B., Bürglin, T.R., Gatto, J., Arasu, P., G. Ruvkun 1991. Negative regulatory sequences in the lin-14 3' untranslated region are necessary to generate a temporal switch during C. elegans development. Genes and Development 5: 1813‑1824.

15. Finney, M. and Ruvkun, G. 1990. The unc-86 gene product couples cell lineage and cell identity in Caenorhabditis elegans. Cell 63: 895‑905.

14. Ruvkun, G., Gilbert, W., Horvitz, H.R. 1990. Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization. Nucleic Acids Research 18: 809‑815.

13. Bürglin, T.R., Finney, M., Coulson, A., and Ruvkun, G. 1989. C. elegans has scores of homeobox genes. Nature 341: 239‑243.

12. Ruvkun, G. and Giusto, J. 1989. The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal switch during development. Nature 338: 313‑319.

11. Ruvkun, G., Ambros, V., Coulson, A., Waterston, R., Sulston, J., and Horvitz, H.R. 1989. Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. Genetics 121: 501‑516.

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